Architectural and thermodynamic principles underlying intramembrane protease function

Architectural and thermodynamic principles underlying intramembrane protease function

Intramembrane proteases hydrolyze peptide bonds within the membrane as a signaling paradigm universal to all life forms and with implications in disease. Deciphering the architectural strategies supporting intramembrane proteolysis is an essential but unattained goal. We integrated new, quantitative and high-throughput thermal light-scattering technology, reversible equilibrium unfolding and re...

Architectural Principles in Arthrodesis

a real advance in the surgery of the hip joint and when well performed has uniformly produced a large percentage of successes in the fusion rate. Mr. Brittain's technique has been modified or altered in several respects by others, but the soundness of his principle has generally been accepted without question. The same is true of his scapulo-humeral arthrodesis of the shoulder, although this is...

Safe Architectural Design Principles

This report discusses architectures for safety-critical sysems. The report summarises the existing literature in the area as well as the guidance provided by existing safetycritical system development standards. We discuss the three constituent functions of fault tolerant architectures: error detection, damage assessment and confinement and error recovery. We also consider methods for fault pre...

Architectural Principles in Arthrodesis

The Search for Underlying Principles of Health Impact Assessment: Progress and Prospects; Comment on “Investigating Underlying Principles to Guide Health Impact Assessment”

Health Impact Assessment (HIA) is a relatively young field of endeavour, and hence, future progress will depend on the planning, implementation and rigorous evaluation of additional HIAs of projects, programmes and policies the world over. In the June 2014 issue of the International Journal of Health Policy and Management, Fakhri and colleagues investigated underlying principles of HIA through ...